Methionine Metabolism and Lung Cancer Lineage Fate

Lung cancer is a devastating disease with high mortality even when diagnosed at an early stage, and it has several distinct subtypes. The two major diagnoses within non-small cell lung cancer, adenocarcinoma (ADC) and squamous cell carcinoma (SCC), are historically treated as separate diseases. However, mounting evidence shows that reprogramming from ADC to a more SCC fate allows lung cancers to evade therapies. The proposed studies aim to understand how cellular metabolism influences this cellular reprogramming by using mouse models and human lung cancer cells. This research is important for understanding how to influence lung cancer subtype to improve treatment outcomes.