Neuropeptidergic Inhibition of Spinal Pain Transmission

  • Taylor, Bradley (PI)

Grants and Contracts Details


B. Studies and Results. [Aim I involves behavioral studies using NPY and NPY receptor antagonists and deletion mutant mice. We completed the pharmacology component, showing that exogenous (intrathecal) NPY acts at Yl and/or Y2 receptors to reduce behavioral signs of persistent pain, and extended our studies to the braid3These results have been published in the past year in three manuscripts (Smith et al., 2007, Taylor et al., 2007, Intondi et al., 2008): pubMed ID = 17194506, 17276005, and 17976913, respectively. Aim 2 proposed microdialysis and immunohistochemistry studies to evaluate NPY and Yl receptor expression in the spinal cord~JSome of the results obtained with NPY immunohistochemistry were published this past year in a manuscript mentioned above (Smith et al., 2007). Other NPY and Yl studies are now completed, were presented at SFN 2007 in San Diego, and will be submitted for 4 publications during the 08-09 fiscal year of this project. An example of this data is described in Fig 1-2. fAim 3 proposed Fos, microdialysis, and NK1 internalization studies to evaluate spinal neuron activation in the setting of acute pain] We have published the Fos data in a manuscript mentioned above. An example of this data is described in Fig 3.
Effective start/end date9/10/021/31/10


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