Grants and Contracts Details
Description
Scope of Work-University of Kentucky
The Sun and Gentry lab established a high throughput metabolomics and MALDI pipeline that utilizes high-
resolution mass spectrometry and bioinformatics software developed internally for rapid comprehensive profile
of polar metabolites and glycogen/carbohydrate molecular imaging. The goal of this R01 subcontract project is
to facilitate Dr. Nirbhay Yadav to further decipher the metabolic perturbations mouse model of
neurodegeneration, with a strong focus on terminal glycogen levels and associated metabolites. Dr. Yadav will
use the Sun/Gentry lab’s metabolomics and MALDI imaging expertise to 1) define the metabolism and disease
pathology of mouse models of neurodegeneration and aging; 2) define the glycogen structure in association
with NMR defined glycogen distribution in live mouse brains; and 3) to determine neuropathology in mouse
models of neurodegeneration. Dr. Sun, Dr. Relich, Dr. Gentry, and Dr. Bruntz will assist in sample preparation,
data curation/batch analysis, and system level interpretations. There will be machine time (GCMS and MALDI)
available for Dr. Yadav’s planned experiments and current estimated sample size. Dr. Sun, Dr. Relich, Dr.
Bruntz, and Dr. Gentry will have regular meetings over zoom with Dr. Yadav to evaluation project progression
and offer help on manuscripts preparation.
Status | Finished |
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Effective start/end date | 4/1/22 → 10/31/22 |
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