Novel Effectors of TGF-Beta Signaling in Prostate Growth Regulation and Tumor Progression

Grants and Contracts Details


Transforming growth factor-B (TGF-B) is a negative regulator of normal, benign and malignant prostate growth. Whiel serving a growth-inhibitory/apoptic role in the normal prostate, overproduction of TGF-B1 in the aging prostate contributes to the development of benign prostate hyperplasis (BPH) and prostate cancer. In this propoal, we hypothesize that TGF-B1 signaling via changes in Smad4-independent intracellular effectors and cross-talk with the adrogen receptor (AR) regulates prostate growth, and functional inactivaion of this network accelerates the manifestation of the malignant phenotype and tumor progression.
Effective start/end date8/15/107/31/15


  • National Institute Diabetes & Digestive & Kidney: $1,257,912.00


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