Novel Phenotypic Predictors of Response to Neoadjuvant Chemotherapy in Bladder Cancer

  • James, Andrew (PI)
  • Kyprianou, Natasha (CoI)

Grants and Contracts Details


We propose that phenotypic changes in the landscape of urothelial tumors at the time of transurethral resection will predict response to NC and allow more appropriate selection of patients with muscle invasive bladder cancer who would benefit from NC prior to RC. Our hypothesis is that the epithelial-mesenchymal-transition (EMT) landscape of the tumor tissue and protein effectors regulating the progression of EMT will allow identification of key effectors of cellular behavior and therapeutic response to NC.
Effective start/end date12/1/1612/15/17


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