NRSA Fellowship/Klein: Cocaine and Sucrose Cross-Sensitization in Rats

Specific Aim I: To detennine whether previous cocaine exposure increases the value of sucrose as measured by (a) increased willingness to work and (b) increased consumption. This aim is important because it explores how and why addictions co-occur and the reasons why recovery from one addiction may leave individuals vulnerable to future addictions. Specific Aim 2: To detennine whether sucrose produces cross-sensitization to cocaine as measured by (a) conditioned place preference and (b) increased locomotor activity. This aim is important because it investigates whether high sugar diets increase vulnerability to future addictions (an issue that is very relevant to children growing up in the United States today)