Projects and Grants per year
Grants and Contracts Details
Description
The objectives of the Molecular Mechanisms of Toxicity Training Program are to provide trainees with an
education in the cellular and molecular mechanisms by which environmental agents induce human disease. The
training program is based on an understanding of biochemistry, molecular/cell biology, pharmacology, and
toxicology, and is coupled with in-depth laboratory research training. The Training Program is based in the
Graduate Center for Toxicology (GCT), a basic science department in the College of Medicine that grants the Ph.D.
in Toxicology and provides an administrative and teaching nucleus of 11 Core Faculty. Joint Faculty from
Medicine, Pharmacy, Agriculture, and Arts & Sciences enrich the diversity of training opportunities; 25 of these
Core and Joint Faculty with strong research programs make up the Training Grant Faculty. This competitive
renewal application requests support for 4 pre- and 2 postdoctoral trainees; it is focused on three disease areas
with an environmental basis: Cancer, Cardiovascular Disease and Neurodegenerative Disease. Oxidative stress
and DNA damage and repair are mechanistic themes that underlie many of the research programs, providing
opportunities for collaborations and multidisciplinary approaches that enrich the research training. The
Predoctoral training program requires Biomedical (25 credits) and Toxicology Bases (13 credits) and an Elective
(2-4 credits). Predoctoral trainees will be supported for a maximum of 3 years (e.g., years 2 - 4 of doctoral
training; Postdoctoral trainees will be supported for a minimum of 2 years. PhD Fellows will be recruited within
3 years of their degree, while MD Fellows will be recruited upon completion of their residency training; we
anticipate a ratio of 2 PhDs to 1 MD. Postdoctoral trainees are required to enroll and participate in 2 credits of
Environmental Exposure and Human Disease in addition to a rigorous laboratory experience. Currently, 28
students are enrolled in the Toxicology PhD program, including 6 minority students, most of whom were
recruited from the University of Puerto Rico and supported by summer research/education grants. The
University provides strong support for the GCT in the form of student fellowships, supplementation to this
Training Grant, and faculty lines, space and equipment to enhance and sustain a strong toxicology program.
Status | Finished |
---|---|
Effective start/end date | 7/1/90 → 6/30/12 |
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Projects
- 1 Finished
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SCOPE: Unliquidated Obligations for NRSA T32: Training Grant in Molecular Mechanisms of Toxicity
Vore, M. (PI) & St Clair, D. (CoI)
7/1/11 → 6/30/12
Project: Research project