PAR2, Bronchopulmonary Sensory Nerve and Pathogenesis of Asthma

Grants and Contracts Details

Description

Principallnvestigator/Program Director (Last, first, middle): Gu, Qihai Project Summary/Abstract Protease-activated receptor-2 (PAR2) is expressed in various cells in the airways and lungs. Increasing evidence has suggested that activation of PAR2 contributes to airway inflammation and airway hyperresponsiveness, the prominent features of many respiratory diseases including asthma. The mechanism underlying the potent actions of PAR2 in the airways and lungs remains to be elucidated; and an involvement of neurogenic mechanisms caused by the activation of bronchopulmonary sensory nerves, particularly C-fiber afferents has been recently suggested. is to eluc'lda ThE: in-\/ivo out in thc:!proposed studies The results obtained from this proposal should improve our understanding of the pathogenic role of the interaction between PAR2 and bronchopulmonary sensory nerves, and offer novel therapeutic strategies for the treatment of airway inflammatory diseases such as asthma. Project Description Page 6
StatusFinished
Effective start/end date7/1/085/31/11

Funding

  • National Institute of Allergy and Infectious Diseases: $146,500.00

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