Grants and Contracts Details
Description
The epidemics of opioid prescribing, injection drug use, overdose, and infectious disease
transmission intersect in rural America. The National Rural Opioids Initiative recently funded by
NIDA, CDC, and the Appalachia Regional Commission, is a multi-state consortium designed to
study interventions that increase access to care and reduce opioid overdose deaths and
infectious consequences of opioid use in rural America. Sites have just initiated recruiting an
initial cohort of people who use opioids in rural areas using harmonized respondent-driven
sampling (RDS). Participants complete rapid HIV, hepatitis C, and syphilis testing along with a
single drug use and behavioral risk assessment using a survey instrument harmonized across
states. Clinical and Translational Science Award (CTSA) sites and the NIDA Clinical Trials
Network (CTN) are well-positioned to partner with the National Rural Opioids Initiative to
determine optimal practices for recruiting and retaining study participants with opioid use
disorder in rural America. We propose to test the use of peers recruited through RDS to improve
clinical research participant retention among people who use drugs in rural America. This study
leverages the Rural Opioids Initiative sites in Kentucky, Ohio, and Oregon, where an initial
round of recruitment is already funded, but long-term follow-up plans are variable. CTSA
support would increase capacity for follow-up at 6, 12, 18, and 24 months and testing retention
strategies. The proposed study would compare the impact of an innovative peer-driven study
retention strategy to a standard retention strategy (e.g., staff follow-up and appointment
reminders via text, phone, and/or mail) on study retention at 6, 12, 18, and 24 months.
Participant willingness to participate in future clinical trials for treatment of opioid use disorder is
a secondary outcome. In depth qualitative interviews will assess participant’s views of study
participation, retention, and priorities for participating in future clinical trials. The primary goal of
the study is determine the optimal strategies for recruiting and retaining people who use opioids
in rural America.
Status | Finished |
---|---|
Effective start/end date | 9/18/18 → 7/31/24 |
Funding
- Oregon Health and Sciences University: $244,894.00
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