Grants and Contracts Details
Description
Characterize the extent of fluconazole inhibition of drugs with varying degrees of fraction metabolized (Fm) by CYP2C9 in individuals with the CYP2C9*1/*3 and CYP2C9*3/*3 genotype and apply an enzyme based pharmacokinetic model developed for the CYP2C9 enzyme to determine the change in exposure due to inhibition across drugs with a range of Fm values..
| Status | Finished |
|---|---|
| Effective start/end date | 8/15/10 → 7/31/15 |
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