Grants and Contracts Details
Description
Thep harmacokineticosf a standardtr eatmentr egimeno f piperacillihna ven everb eend escribedfo r
hospitalizepda tientso n chronicin termittenht emodialysisS.i ngled oses tudiesin otherwiseh ealthy
volunteersh aves hownt hat thisp atientp opulationh asa prolongedh alf-lifea nda reau ndert he curvea s
well asd ecreasecdl earanceT. hiss tudyw ill enroll1 0 hospitalizepda tientsw ith chronick idneyd isease
on intermittenth emodialyswish o arer eceiving2.25gqm8 ho f piperacillin/tazobactaOmu. ro bjectives
aret o characterizteh e pharmacokinetpica rameterosf thisa genti n thisp atientp opulationa ndt hent o
performa MonteC arlos imulationto determineth e expectedp harmacokinetic/pharmacodynamic
targeta ttainmenta gainsbt acteriaw ith a rangeo f MlCs.S ubjectws ill be includedif they havec hronic
kidneyd iseaser,e ceivein termittenht emodialysfios r at least6 months,a ndh avea documentedo r
suspectedin fection.E xclusiocnr iteriain clude< 18y earso f age,c oncomitanlti verd iseasep, regnancyo,r
historyo f allergyto penicillinosr cephalosporinsB.l oods amplesw ill bec ollectedo n inter-dialysdisa ys
immediatelyb eforea doseo f piperacillin/tazobactaamnd, t hen3 0 minutes!,, 2,4, and8 hoursa fter
the infusionis s tarted.A dditionabl loods amplesw ill be collectedim mediatelby eforea nd L houra ftera
dialysis essionS. amplews ill be analyzedfo r piperacillicno ncentrationuss ingh igh-pressurlieq uid
chromatographyT.h ep opulationp harmacokinetpica rameterws ill then be usedi n a 10,000p atient
MonteC arlos imulationth at will evaluateth e probabilittyh at a targett ime greatert han MICo f 50%i s
achievedo vera rangeo f MlCs.T hee xpectedo utcomei st hat this recommendeddo singr egimenis
appropriatefo r organismws ith an MICs 16mcg/mLo wingt o the similaritieosf thisp opulation's
piperacillicno ncentration-timceu rvet o an extendedin fusionr egimenin individualws ith normalr enal
fu nction.
Status | Finished |
---|---|
Effective start/end date | 1/10/12 → 7/31/14 |
Funding
- ASHP Foundation: $4,823.00
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