Projects and Grants per year
Grants and Contracts Details
Description
Adipose tissue has become well-known for its role in chronic metabolic diseases such as diabetes and cardiovascular disease. Inflammation originating from the adipose tissue appears to be an underlying contributor to these chronic conditions. To date, the majority of research in this field has focused on obesity without regard for aging, despite the fact that aging often poses a larger risk. It has recently become evident that the mechanisms governing age-related and obesity-mediated adipose tissue dysfunction are different, thus a major knowledge gap in the field of aging exists and needs to be filled. This proposal is centered on our novel finding of a dramatic age-associated expansion of gamma delta yo T cells in visceral adipose tissue. The hypothesis of the project is that age-associated chronic adipose tissue inflammation is mediated by expanded yo-T cell populations in visceral adipose tissue. As there is a growing population of adults who have suffered from obesity since childhood, the effects of long-term obesity in combination with aging will be investigated. The Specific Aims of this pilot project are designed to provide robust preliminary data in support of the hypothesis. Specific Aim 1 will demonstrate that aging with obesity further alters adipose tissue physiology compared to aging or obesity alone. This aim will include experiments to define age- and obesity-mediated changes in yo-T cells populations. Specific Aim 2 will establish that yo-T cells play a role in chronic inflammation using mice genetically deficient in yo-T cells (TCRo-/-). The role of these cells in glucose homeostasis, and their potential to influence inflammation will be tested. Completion of the proposed project will establish whether ãä-T cell populations are altered by aging, obesity, or aging with obesity in similar fashions, and provide novel information linking these cells to chronic metabolic diseases among obese elderly. The generated data will strengthen the scientific premise of the PIs overall project and greatly enhance competitiveness of the project for external funding.
Status | Finished |
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Effective start/end date | 9/8/08 → 7/31/17 |
Funding
- National Institute of General Medical Sciences
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Projects
- 1 Finished
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COBRE: Center of Research in Obesity and Cardiovascular Disease COBRE Core A: Administrative
Cassis, L. (PI), Abdel-Latif, A. (CoI), Charnigo, R. (CoI), Daugherty, A. (CoI), Gong, M. (CoI), Graf, G. (CoI), Johnson, L. (CoI), Katz, W. (CoI), Kern, P. (CoI), Morris, A. (CoI), Pearson, K. (CoI), Pendergast, J. (CoI), Powell, D. (CoI), Randall, D. (CoI), Smyth, S. (CoI), Subramanian, V. (CoI), Tannock, L. (CoI), Temel, R. (CoI), Thompson, K. (CoI), Van Der Westhuyzen, D. (CoI), Wang, S. (CoI), Webb, N. (CoI), Yiannikouris, F. (CoI), Zhou, C. (CoI) & Vandsburger, M. (Former CoI)
National Institute of General Medical Sciences
9/8/08 → 7/31/17
Project: Research project