Pilot Project-Yosra Mohamed :COBRE in Pharmaceutical Research and Innovation

Grants and Contracts Details

Description

Salmonella is the leading cause of bacterial foodborne poisoning with significant public health importance worldwide (1). Poultry products (eggs and poultry meat) are considered to be the main source of Salmonella infections in humans (.f, J). Human-causing Salmonella serotypes do not cause disease in birds, but they colonize their intestines, multiply, and cause food poisoning in humans (1_). Salmonella was isolated from approximately 9-12% of the samples from poultry production (_§_, §). Economically, one of the food industry''s biggest threats to profitability is food recalls. According to Food Safety Reports, the number of food recalls in the USA has increased dramatically in the last few years, and recently Salmonella alone accounted for the greatest number of FDA-regulated food recalls (I). Currently, Salmonella infections in poultry are controlled by antibiotics and/or vaccination, however, their effect is limited due to the emergence of antibiotic­resistant strains (§_,??)-Additionally, the live Salmonella vaccines are not effective in reducing food poisoning, and there is the risk of live bacteria getting into the human food chain (1Q). Therefore, there is a critical need for antibiotic alternatives to control infection in poultry and mitigate the risk of Salmonella food poisoning and antimicrobial resistance in humans. Quorum sensing autoinducer-2 (QS Al-2) plays a critical role in pathogenicity, virulence, biofilm formation, motility, genetic competence, sporulation, and antibiotic production of several bacteria including Salmonella (11). Al-2 is unique because it serves as the universal signal between interspecies QS communication for Gram-negative and Gram-positive bacteria (1.f). Therefore, inhibition of QS Al-2 activity using QS inhibitors (QSI) can be a potential novel strategy for antibacterial development. As the QSI does not interfere with the metabolic processes of a bacterial cell such as protein synthesis, DNA metabolism, and cell wall formation which are the targets for the development of drug resistance, they will not exert selection pressure on the bacteria during treatment, thus bacteria are less likely to develop resistance.
StatusFinished
Effective start/end date3/1/201/31/23

Funding

  • National Institute of General Medical Sciences

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