PostDoctoral Fellowship for Reynolds: Perinatal tobacco exposure and mechanisms of offspring obesity and insulin resistance

Grants and Contracts Details


Maternal smoking increases offspring risk for a number of diseases including pediatric and adulthood obesity and type 2 diabetes. Despite this knowledge, 20-30% of pregnant women continue to smoke throughout pregnancy and nursing. Many unanswered questions remain on the mechanisms leading to increased obesity risk in offspring exposed in utero to tobacco smoke, particularly in human offspring. Further, the adverse effects of nicotine from maternal smoke exposure do not end in utero. Nicotine from smoking mothers is present in breast milk. Thus, maternal smoking during lactation exposes offspring to the detrimental effects of nicotine. It is currently not known if tobacco smoke exposure in utero or during nursing (or both) is most critical for the development of adult offspring obesity. The overall purpose of this proposal is to examine mechanisms of metabolic programming to in utero smoke exposure in humans and the critical timeframe of smoke exposure which results in the worse metabolic and obesity prone profile.
Effective start/end date7/1/156/30/17


  • American Heart Association Great Rivers Affiliate: $89,000.00


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