Grants and Contracts Details
Description
Abstract
Trauma is a leading cause of death for all ages; exsanguination is the primary preventable
cause of death. Standard care for hemorrhage includes infusing crystalloid and blood products.
Changes occur in stored blood components affecting cellular structure and oxygenation ability;
neurons are particularly sensitive to these changes. Few studies have evaluated outcomes
associated with blood transfusions beyond survival and adverse events. This study will evaluate
the association of blood transfusion volume, ratio of components, and age of stored blood
components with cognitive/psychological functioning in trauma patients. We will use a
prospective, repeated measures design, recruiting a convenience sample of critically injured
adult trauma patients who receive a blood transfusion within 24 hours of admission, and one
family member per patient. We will evaluate cognitive/psychological functioning once during
hospitalization and again four weeks after discharge using: modified Telephone Interview for
Cognitive Status (mTICS), Short Form Health Survey-36, Patient Health Questionnaire-9,
Awareness Questionnaire (patient and family), and Disability Rating Scale (family member
only). Paired t-tests will compare pre- and post-test scores for all instruments. Multiple linear
regressions will determine the relationship between volume of transfused components and ratio
of transfused blood components and resulting cognitive/psychological function at four weeks
post-discharge. Logistic regression will determine the relationship between volume of transfused
components and ratio of transfused blood components and resulting cognitive function (< 38 on
the mTICS indicating cognitive impairment). Results could significantly influence evaluation of
transfused trauma patients, and support rehabilitation and achievement of maximal functional
outcomes.
Status | Finished |
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Effective start/end date | 8/1/14 → 7/31/15 |
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