Redox Modulation of Skeletal Muscle Function in Microgravity

Gravitational unloading causes weakness of antigravity muscles due to loss of muscle mass (atrophy) and contractile dysfunction. In selected conditions, especially extravehicular activity (EVA), performance can also be limited by muscle fatigue. This research evaluates selected compounds, nutritional supplements and pharmacologic agents that may oppose oxidative stress in muscle and protect against weakness and fatigue.