Reevaluation Of Systemic Early Neuromuscular Blockade (ROSE) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network

Reevaluation Of Systemic Early Neuromuscular Blockade (ROSE) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Site will screen and enroll subjects following ROSE study protocol. Staff will also participate in trainings, conference calls and assist with study monitoring. Study personnel will complete all protocol activities including lab collection, data collection, surveys, and subject follow-up. Site will also keep appropriate study and regulatory documentation. Objective: To assess the efficacy and safety of early neuromuscular blockade in reducing mortality and morbidity in patients with moderate-severe ARDS in comparison to a control group with no routine early neuromuscular blockade. Study Design: Multi-center, prospective, 2-arm, unblinded, randomized clinical trial of two management strategies of neuromuscular blockade (also called skeletal muscle relaxant and muscle relaxant).