Projects and Grants per year
Grants and Contracts Details
Description
A. Specific Aims - Project I
The specific aims of this project have not changed since the review of this grant For clarity they are detailed
as follows: Hypothesis: Combined putamenal and substantia nigra delivery of GDNF
will contribute to enhanced improvement of MPTP-lesioned monkeys. In these studies, chronic
parenchymal catheters will be placed in both the substantia nigra and the putamen, and chronic delivery of
GDNF will be compared in these animals to monkeys receiving a single catheter placement into the
putamen. A battery of behavioral (Project 2), neurochemical (Project 1), histopathological (Project 3),
immunocytochemical (Project 3) and biochemical (Projects I and 3) measures will be used to investigate
the functional consequences of five months of delivery of GDNF.
Hypothesis: Using an optimized delivery approach, GDNF will more
completely restore nigrostriatal DA functions in milder versus severely impaired MPTP-treated
monkeys. In these studies, stable milder-impaired versus stable severely impaired unilateral MPTP-treated
monkeys will be used to investigate the effects of chronic delivery of GDNF. An optimized cannula delivery
system will be used to chronically deliverGDNF in these animals.
Hypothesis: GDNF administration will affect glutamate regulation in the
striatum, substantia nigra and globus pallidus of severely parkinsonian rats. This is new direction of
the Center, which embodies collaborations with other Udall Centers. A newly developed but well
characterized glutamate microelectrode recording system will be used to study basal and potassium-evoked
release and uptake of glutamate in the striatum, substantia nigra and globus pallidus of severely
parkinsonian rats (6-ONDA-treated animals) that have received injections of GDNF into the substantia
nigra.
Status | Finished |
---|---|
Effective start/end date | 9/30/99 → 1/31/12 |
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Projects
- 1 Finished
-
Restoration of Dopamine Function in Parkinson's Disease
Gerhardt, G., Andersen, A., Bradley, L., Gash, D., Grondin, R., Hardy, P., Kryscio, R., Markesbery, W. & Zhang, Z.
National Institute of Neurological Disorders & Stroke
9/30/99 → 1/31/12
Project: Research project