Scope: Altering Post-Traumatic Osteoarthritis After Patellar Dislocation: Blood Flow Restriction Training, Aspiration, and Intraarticular Normal Saline (BRAINS Trial)

Grants and Contracts Details


Patellar dislocations are more common in military personnel and athletes than in the civilian population. In the short-term, muscular impairment after patellar dislocation impacts military readiness and in the long-term, patellar dislocation often leads to posttraumatic osteoarthritis (PTOA) within 5 to 15 years after injury. Physical therapy is the standard of care after patellar dislocation; however, despite the risks of PTOA and functional impairment after patellar dislocation, the conservative treatment of these injuries has remained largely unchanged over the past 20 years. There is no consensus on best practices and current treatment algorithms do not address both biologic and biomechanical mechanisms of PTOA. The purpose of this study is to determine if knee aspiration and saline injection or blood flow restriction training (BFRT), either individually or combined, will improve outcomes after patellar dislocation. The proposed study directly relates to the FY19 PRMRP Topic Area of Post-Traumatic Osteoarthritis (PTOA). The proposed multidisciplinary study addresses three Areas of Encouragement related to PTOA: 1) Studies to evaluate and develop best practices for multidisciplinary team approaches and treatment algorithms for post-traumatic osteoarthritis, 2) Intra-articular treatments that offer sustained (2 or more months) relief of symptoms and/or disease-modifying effects, and 3) Development of innovative rehabilitation approaches for preventing or mitigating PTOA. The results of this study will benefit military personnel and civilian patient populations to improve clinical outcomes after patellar dislocation, promoting a safe return to activity while also reducing degenerative changes to both the cartilage and muscle. The low cost and simplicity of the interventions will allow for immediate implementation in clinical practice in military and civilian settings.
Effective start/end date7/1/206/30/25


  • Army Medical Research and Materiel Command


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