Grants and Contracts per year
Grants and Contracts Details
Description
With population aging and increasing comorbidity, a growing number of patients develop metabolic bone
diseases (MBD) such as osteoporosis and renal osteodystrophy from the associated effects on bone turnover and
mineralization. Conditions such as kidney disease, organ transplant, bariatric surgery, cancer, HIV/AIDS, glucocorticoid
use and other diseases, result in a significant increase in MBD. Over the past decade, therapeutic options for MBD
have expanded rapidly, creating opportunities for targeted treatments. A bone biopsy is the current gold standard for
diagnosing the specific type of MBD and facilitates the optimal use of bone-active agents in treatment. It provides
information about the mineralized component of bone: turnover, mineralization and microarchitecture.
In practice, bone biopsies are performed with trephines that were designed primarily to harvest bone marrow
even though both tissues are processed very differently. Qualitative and quantitative histology for a bone biopsy is
performed on un-decalcified sections cut from hard resin- or polymer- embedded blocks, preserving the cortical and
trabecular microarchitecture. The modern trephines still use a manual technique, and often yield suboptimal bone
tissue cores with inadequate preservation of microarchitecture. The manual biopsy technique requires significant
training for the operator and is painful to the patient. Power drill modifications, while easier and less painful, yield
small cores and produce damage artifacts and debris from an inappropriately designed cutting edge paired with a
high-speed drill. These known problems with bone biopsy technology ultimately decrease provider and patient
acceptance reducing the accuracy of diagnosis, underscoring the technology gap in meeting the need for appropriate
tools.
Status | Finished |
---|---|
Effective start/end date | 5/1/20 → 6/30/21 |
Funding
- KY Economic Development Cab
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Projects
- 1 Finished
-
State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#)
Dwoskin, L., Abdel-Latif, A., Bruntz, R., Cassidy, R., Delisle, B., Feola, D., Gensel, J., Gentry, M., Gordon, S., Lima, F., Malluche, H., Rao, M., Sun, R., Venditto, V., Zhan, C. & Zheng, F.
5/1/20 → 6/30/21
Project: Research project