Stable Isotope-Derived Metabolomics to Elucidate the Mechanism of a Tumor-Associated Cytochrome in Lung Cancer Growth and Metabolism

Grants and Contracts Details


This proposal will address the pressing issue of the lack of robust biomarker(s) for routine diagnosis of lung cancer, the leading death-causing cancer in the U.S. The approach we are taking is novel as it fingerprints the differences in metabolic regulation between paired normal and cancerous lung tissues obtained from the same patient. This eliminates interferences due to person to person variability. At the same time, we will determine the metabolic profiles of the readily available biofluids plasma, bronchoalveolar lavage fluid, and/or urine from the same lung cancer patients. The fundamental mechanistic knowledge obtained from the tissue will then be translated into identifying specific biochemical marker(s) of early stage lung cancer and development in these biofluids, that are linked to . the distinctive metabolism of lung cancer tissues. This will form the basis of sensitive and robust noninvasive diagnostic tests of lung cancer.
Effective start/end date12/1/105/31/13


  • KY Lung Cancer Research Fund: $150,000.00


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