Studies in Gastrointestinal Endocrinology

Dr. Evers' research plans have not been altered by the move to the University of Kentucky. The current research plans will continue as stated in the original proposal, and the lab will continue to carry out the following Specific Aims: 1) To determine the role of the P13K1Akt pathway in the age-associated alteration of pancreatic growth. 2) To elucidate the role of IGF-1 and its receptor on altered P13K1Akt expression and proliferation. 3) To further delineate alterations in the P13K1Akt signaling pathway and upstream effector proteins in isolated acinar cells from young and aged pancreas. Their studies, utilizing novel in vivo and in vitro models, will continue to challenge previous concepts and Viewpoints regarding the aging process. Finally, in collaboration with the other projects and cores in the Program Project Grant, the studies will continue to address clinically relevant questions of GI health and disease with aging, which will translate to a better understanding of the effects of aging on the GI tract and possibly lead to novel therapies. The removal of Dai H. Chung from the project will in no way affect the completion of the aims of the project. Dr. Hiroshi Saito will remain on the project as a Co-Investigator; Dr. Saito is also relocating to the University of Kentucky as of July 2009.