Supplement for CORY WHITE: Regulation, signaling, and dynamics of glucan phosphatases

  • Gentry, Matthew (PI)

Grants and Contracts Details

Description

The objective of this grant is to elucidate the regulation, downstream signaling, and structural dynamics of the glucan phosphatase laforin. Mammalian cells store readily-mobilized energy in the form of glycogen, a water-soluble, cytoplasmic carbohydrate/glucan. When certain aspects of glycogen metabolism malfunction, cells develop insoluble, poorly branched, hyperphosphorylated glucans called Lafora bodies (LBs) (1-6). Therefore, mammalian cells both actively synthesize soluble glycogen and inhibit the accumulation of insoluble glucans, i.e. LBs. Humans develop LBs as a consequence of an autosomal recessive neurodegenerative disorder known as Lafora disease.
StatusFinished
Effective start/end date7/1/104/30/14

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