Projects and Grants per year
Grants and Contracts Details
Description
Abstract/ scope of work proposed
Obesity promotes hypertension, a major risk factor for cardiovascular disease. Epidemiological
studies have linked early life stress as a modifiable risk factor for increased body mass index
and blood pressure. Using an advantageous mouse model of early life stress that combines
postnatal maternal separation and early weaning (MSEW) with a high fat diet, we have
identified two potential adipose tissue-derived targets implicated in the pathways by which these
mice display exacerbated obesity-induced hypertension. Our preliminary findings support the
novel central hypothesis that postnatal MSEW aggravates obesity-induced HT in adult life by
stimulating adipose afferent reflex (AAR)-mediated sympathetic activation and adipose tissue-
derived angiotensinogen (AGT) secretion. We will test key predictions in two multilevel specific
aims: (1) To test the hypothesis that MSEW heightens obesity-induced hypertension by
stimulating adipose tissue excitatory signals to increase AAR reflex. In this aim, the
applicant will contribute to determine the different neurons that are activated in response to
MSEW mice fed a high fat diet and test the afferent reflex in vivo in female mice; and (2) To test
the hypothesis that MSEW exacerbates obesity-induced hypertension by increasing AGT
secretion in adipose tissue. The applicant will contribute to determine whether changes in
circulating angiotensin II influence the activation of the circuventricular organs (CVO).
Status | Finished |
---|---|
Effective start/end date | 12/1/17 → 7/31/22 |
Funding
- National Heart Lung and Blood Institute
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Projects
- 1 Finished
-
Effect of Early Life Stress on Obesity-Induced Hypertension in Mice
Loria Kinsey, A., Cassis, L., Gong, M., Yiannikouris, F., Nixon, K., Osborn, J. & Pauly, J.
National Heart Lung and Blood Institute
12/1/17 → 11/30/23
Project: Research project