Projects and Grants per year
Grants and Contracts Details
Description
The human gut houses trillions of microbes (“gut microbiome”) that are essential to health and
immune system function. Changes in diet, infections, and, importantly, antibiotics result in
profound shifts to the gut microbiome that can have long-term impacts on health. These
disruptions in the community of microbes, referred to as dysbiosis, have been linked to various
autoimmune and inflammatory diseases, as well as cardiovascular disease and depression. Yet
to be investigated is the contribution of microbiome dysbiosis to Post-treatment Lyme Disease
Syndrome (PTLDS), a poorly understood, complex, often disabling post-infection condition that
follows standard antimicrobial therapy for Lyme disease. In this study we will for the first time,
assess the potential role of dysbiosis elicited by Borreliella burgdorferi infection, alone and in
association with antibiotic treatment, on the outcome of infection and the conditions for PTLDS in
a non-human primate model. We will carry out an in-depth analysis of host responses to uncover
how shifts in the gut microbiome influence inflammatory or other responses. These studies will
provide novel insights into the interaction between Borreliella burgdorferi infection, antibiotics, and
the gut microbiome that may lead to more effective ways to treat Lyme disease, prevent post-
infection sequelae, and manage PTLDS.
Status | Finished |
---|---|
Effective start/end date | 12/5/23 → 12/4/24 |
Funding
- Global Lyme Alliance
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Projects
- 1 Finished
-
Impact of Borreliella Burgdorferi Infection, Immunity, and Antibiotics on the Host's Microbiome in a Nonhuman Primate Model of Lyme Disease
Messaoudi Powers, I. (PI) & Stevenson, B. (CoI)
12/5/22 → 12/4/24
Project: Research project