Projects and Grants per year
Grants and Contracts Details
Description
An administrative supplement to support an undergraduate summer research
experience for rising senior Sarah Sprigg is requested. Sarah will carry out some
of the investigations proposed in Aims 1 and 2 of the parent grant. Specifically,
she will explore the utility of a fluorescent fusion construct of insulin-degrading
enzyme (IDE) in following enzyme localization in cultured live cells. She will also
use the construct to evaluate potential non-localizing mutants and the proposed
close interaction with insulin in endosomes. This research experience will provide
many opportunities for Sarah to enhance her scientific, communication, and
career skills. She will follow a structured protocol in designing experiments,
aimed at giving her experience in developing and testing hypotheses and gain
further experience in documenting her research activities. She will learn
mammalian cell culture techniques, sophisticated light microscopy,
CRISPR/Cas9 technology, as well as the use of FRET to demonstrate the close
proximity of molecules in cells. Sarah will present her work in regular group
meetings, our university’s showcase of undergraduate scholars, and the annual
state undergraduate research event. In addition, Sarah will participate in a
student led journal club in the department, write up her summer studies in the
form of a manuscript, and submit her work for presentation at the National
Conference of Undergraduate Research. Finally, Sarah will register with and
participate in programs provided by our Office of Undergraduate Research, which
will further expand her contact with students interested in research and career
mentors.
Status | Finished |
---|---|
Effective start/end date | 9/1/19 → 7/31/21 |
Funding
- National Institute of General Medical Sciences
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Projects
- 1 Finished
-
Insulin Degrading Enzyme: Physiological Function and its Spacial and Activity Modulation
Hersh, L. (PI), Tannock, L. (CoI), Rodgers, D. (CoPI) & Galperin, E. (Former CoI)
National Institute of General Medical Sciences
9/1/19 → 7/31/24
Project: Research project