Supplement to Prebiotics Intervention to Reduce Alzheimer's Disease Risk via Brain-Gut Axis in an APOE4 Mouse Model

Scope of Work at the University of Kentucky (RF1AG062480; PI: Lin, Subcontract PI: Hartz) Title: “Prebiotics Intervention to Reduce Alzheimer''s Disease (AD) Risk via Brain-Gut Axis in an APOE4 Mouse Model”. The RF1 funding consists of a parent grant and an Administration Supplement award. The overarching goal of the project is to determine if dietary interventions can be used to modify gut microbial composition and activity, which will consequently protect brain vascular and metabolic functions, and reduce neuroinflammation for individuals who posse high risk factors for Alzheimer’s disease (AD), such as having the Apolipoprotein ε4 (APOE4) allele or traumatic brain injury (TBI). A dietary supplement containing prebiotic Inulin will be used in this project. In the parent grant, the effects of APOE4 will be studied while effects of TBI will be investigated in this Supplement award. The PI, Dr. Ai- Ling Lin, has recently moved to the University of Missouri-Columbia, and Dr. Anika Hartz will the subaward PI at the University of Kentucky. Dr. Hartz will oversee the funding distribution and expenses related to existing UK graduate students Lucille Yanckello, Ya-Hsuan Chang, Xing Xing, and Subash Khanal. These students are currently in Dr. Lin’s lab at the University of Missiouri-Columbia but maintain their student status at the University of Kentucky. As such, this subaward is to facilitate their continued support costs (salary, fringe benefits, tuition, and travel expenses).