Grants and Contracts Details
The scope of the work to be conducted in my laboratory includes the application of our glycorandomization platform to develop a scalable synthesis of a unique preclinical lead (based upon the parent antifungal agent amphotericin). As part of this effort, my lab will develop a chemoenzymatic strategy for production of the target compound using synthetic starting materials generated in the Burke laboratory (PI of the parent grant, University of Illinois). The crude reaction products will be subsequently purified via the Burke laboratory and then their activities studied (both in vitro and in vivo) in relevant fungal models via the Andes laboratory (University of Wisconsin). My lab will also focus on pilot studies to explore the feasibility of developing an engineering producing strain capable of production of the target preclinical lead compound.
|Effective start/end date
|4/1/13 → 1/31/16
- University of Illinois: $81,069.00
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