Projects and Grants per year
Grants and Contracts Details
Description
Deaths from lung cancer are the highest of all cancers in North America and elsewhere and, because of the
long incubation time, are likely to remain so for the foreseeable future. Furthermore, although the 5-year
survival rate of stage I lung cancer is 60-70%, later stage disease has a very poor prognosis. Accurate
detection of asymptomatic early stage lung cancer in individuals at risk is currently unreliable. A better
understanding ofthe basic biochemistry of lung cancers is a prerequisite to mechanism-based reliable early
detection ofthe disease, and to improved approaches to treatment. The very complexity ofthe transformed
cells, and the variable host-tumor interactions, makes the problem refractory to any single approach. A
systems biochemistry approach In which lung cancers are studied at the mechanistic level in the laboratory,
in mouse models and in human subjects offers the opportunity to address the complexity of cancer
development and progression. The use of stable isotope resolved metabolomics provides the necessary
direct biochemical information about lung cancer with minimal processing that is not otherwise available.
This program will address the problem in a 3-pronged approach, based on the following integrated projects:
Project 1: Cellular Systems Biochemistry. Microenvironmental nutrient availability and immune modulation in
lung cancer cells.
Project 2; Preclinical Systems Biochemistry. Using SIRM in Human NSCLC xenograft mouse to determine
biochemical mechanisms of immunomodulator (3-glucan.
Project 3: Translational Systems Biochemistry. Molecular mechanisms of NSCLC and response to p-glucan
by SIRM.
The three projects will use a common mechanistic approach to understanding cancer biochemistry namely
stable isotope resolved metaboloriiics (SIRM) that we have been developing over the last eight years. The
analytical requirements will be met in the SIRM Analytical Core, which also supplies the necessary sample
handling and bioinformatics support for the three projects. Core A provides overall administrative support.
Status | Finished |
---|---|
Effective start/end date | 8/19/14 → 2/29/20 |
Funding
- National Cancer Institute
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Projects
- 1 Finished
-
Systems Biochemistry in Lung Cancer: Toward a Mechanistic Understanding of NSCLC - Core A
Lane, A. (PI), Higashi, R. (CoI), Wang, C. (CoI), Fan, W.-M. (CoPI), Bruno, M. (Former CoI), Fahrenholz, T. (Former CoI), Flight, R. (Former CoI), Martin, J. (Former CoI), Moseley, H. (Former CoI), Somashekar, B. (Former CoI) & Tripathi, P. (Former CoI)
8/19/14 → 2/29/20
Project: Research project