Grants and Contracts Details
Description
A novel yeast screen sensitive to retinoid-X receptor (RXR)
transcriptional activation resulted in the isolation of the rat
homologue of the mouse NPDC-I gene. NPDC-I has been shown to
be involved in the control of neural cell proliferation and
differentiation, possibly through interactions with the cell cycle
promoting transcription factor E2F-I. Although the amino acid
sequence of NPDC-I is highly conserved between mouse, rat and
human homologues, their tissue specific expression varies. A
potential for a direct protein:protein interaction between NPDC-I
and RXR was observed in vitro and NPDC-I facilitated RXR dimer
DNA binding in vitro. Expression of NPDC-I also enhances the alltrans
retinoic acid response in mammalian cell transcription assays.
The present results suggest that NPDC-I functions to enhance
transcription regulating factors~ DNA binding function and
influences retinoid signaling by direct interaction with RXR.
Status | Finished |
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Effective start/end date | 7/1/02 → 1/30/06 |
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