Grants and Contracts Details
Description
As a co-investigator in the TELEX Trial (Northwestern University, PI: Mary McGrae
McDermott, MD), I will measure changes in calf skeletal muscle Type I fiber composition
and satellite cell number in response to the study interventions in frozen human muscle
biopsies shipped to the University of Kentucky from Northwestern University. We have
budgeted for two measures of immunohistochemical analyses of muscle cross-sections
from 24 subjects per year for 5 years. Digital microscopic images, as well as
quantification of the images, will be provided to investigators at Northwestern quarterly.
We will communicate regularly by telephone, email and video conferencing, and I will
attend at least one meeting annually at the Northwestern University. This component of
the TELEX Trial enables us to delineate biologic pathways by which the interventions
may improve functioning in patients with PAD. Identifying biologic mechanisms of these
therapies will help identify new therapies, with similar biologic actions, that improve
walking performance in people with PAD.
Status | Finished |
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Effective start/end date | 8/17/15 → 6/30/19 |
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