Grants and Contracts Details
Description
Although global measures of muscle force and strain magnitude during exercise are often
employed to quantify muscle function or damage, there is evidence that these measures
may not be accurate. Recent studies in our lab have shown that the magnitude of
muscle strain is not a valid predictor of muscle damage or fiber strains in-vivo. This may
be due, in part, to the complexity of force sharing amongst synergists, as well as the
complexity of the muscle architecture, and tendon properties during ambulation and
exercise. Current evidence indicates that muscle fibers are highly mechanosensitve,
thus previously measured regional variations in the adaptive response to eccentric
exercise may be due to the regional variations in fiber strain magnitudes experienced
within compartments of the muscle. Here, we propose to directly measure local
mechanical stimuli within and between synergist muscles in-vivo using an established
animal model of eccentric exercise. This will allow the direct measurement of local fiber
dynamics within and between muscles, and subsequent calculation of the division of
labor between them. In addition, we will determine the relationship between fiber strain
and muscle damage for synergists, and assess the possible interrelationship between
muscle architecture, force sharing and subsequent damage during exercise.
Status | Finished |
---|---|
Effective start/end date | 7/16/09 → 7/15/10 |
Funding
- NATA Research & Education Foundation: $934.00
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