Grants and Contracts Details
Description
Sulfiredoxin (Srx) is a novel gene that is highly expressed in several types of human tumors including
cancers of skin and lung. However, the function of Srx in tumor development has not been well studied. The
primary hypothesis of this study is that Srx has an oncogenic function that may contribute to tumorigenesis
and cancer progression in human. The long-term goal of the project is to understand the function and
molecular mechanisms of Srx in human cancer development and progression, which may provoke novel
strategies for cancer prevention and treatment. The first aim of this study is to test whether genomic loss of
Srx may cause mouse resistant to tumorigenesis in a chemical induced skin or colon carcinogenesis model
(to be completed during the K99 phase). The second aim is to study the function and molecular basis of Srx
in human lung cancer cell migration, invasion and metastasis. The third aim is to characterize proteins that
interact with Srx and to determine how they contribute to the oncogenic function of Srx in human lung cancer
cells. During the K99 phase, we have demonstrated the critical function of Srx in cancer development using
methods including cell culture in vitro, mouse skin and colon carcinogenesis in vivo, and mouse models of
human cancer cell tumorigenesis and metastasis, etc. In the R00 phase, the mechanistic study of Srx
function will be focused on the cell signaling changes and protein-protein interactions using biochemistry and
molecular biology techniques. The successful completion of the proposed research may further the
understanding of the role of Srx in human cancer, broaden the knowledge of antioxidant proteins in
tumorigenesis and cancer progression, and facilitate the development of novel strategies for cancer
prevention and treatment.
Status | Finished |
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Effective start/end date | 4/1/12 → 3/31/16 |
Funding
- National Cancer Institute: $709,268.00
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