Timing of Surgery and Rehabilitation to Optimize Outcome for Patients with Multiple Ligament Knee Injuries: A Multi-Center Clinical Trial

Grants and Contracts Details

Description

Multiple ligament knee injuries are a complex, but not uncommon orthopaedic pathology. Failure to successfully regain knee stability can significantly impact an individual’s ability to return to activity, including employment, and may place the individual at increased risk for further injury and future development of osteoarthritis. We propose to serve as a collaborating site with the University of Pittsburgh for a proposed Clinical Trial Development Award from the Department of Defense to plan a multi-center clinical trial to investigate the effects of timing of surgery and rehabilitation to optimize clinical outcome and return to activity for military personnel and civilians with a multiple ligament knee injury. In the clinical trial, subjects with a multiple ligament knee injury would be randomized to one of 4 groups (early surgery with early ROM, early surgery with delayed ROM, delayed surgery with early ROM and delayed surgery with delayed ROM). Additionally for those patients with injuries that involve fractures, compartment syndrome, vascular injury that precludes early surgery etc. there will be a prospective observational non-randomized arm to the study. The purpose of this proposal is for the planning of the proposed randomized controlled trial over 12 month period time during which a multi-center study protocol will be developed and IRB approval will be obtained at collaborating sites.
StatusFinished
Effective start/end date9/28/15 → 9/27/16

Funding

  • University of Pittsburgh: $4,500.00

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