Tuning Astrogliosis to Promote Neural Plasticity After Stroke

The proposed research aims to manipulate astrocytes in the brain to promote preservation and recovery of brain functions after stroke. Nerve cells depend on astrocytes for survival. In response to brain injury, such as stroke, astrocytes contribute to brain tissue protection, repair, and rebuilding lost nerve connections. In spite of their essential beneficial roles, there is currently no way to stimulate astrocyte activity. We have developed novel genetic tools to amplify or reduce astrocytes’ response to brain injury. With these tools, we will determine how best to tune astrocyte activity to improve recovery after stroke.