Grants and Contracts Details
Description
Goals To define the metabolic consequences of cold stress in T-cells and the influence of tumor burden via adrenergic signaling. Aim 2: To test the hypothesis that adrenergic signaling impairs the antitumor efficacy of CD8+T-cells by impairing metabolic reprogramming. Here we will examine the effects of adrenergic signaling on T-cell glucose metabolism and how this may suppress: 1) T-cell activation, 2) T-cell trafficking and 3) suppression of T-cells in the tumor microenvironment.
Status | Finished |
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Effective start/end date | 12/19/17 → 11/30/23 |
Funding
- Health Research Incorporated: $438,155.00
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