University of Kentucky Alzheimer's Disease Core Center: Pilot Project 14.2 Developing a New Statistical Tool to Examine the Associations Between Rare Variants and LOAD-Related Ordinal Phenotype

Grants and Contracts Details

Description

Aim 1: develop a new statistical approach to examine the associations between rare variants and an ordinal variable outcome to address ordinal data structure. Aim 2: apply this proposed approach for the dataset of the UK ADC neuropathology (NP) linked to the Alzheimer's Disease Sequencing Project (ADSP) Whole Exome Sequence (WES) and Whole Genome Sequence (WGS) data to identify novel rare variants associated with LOAD-related pathology and thus provide a new tool for UK ADC data mining.
StatusFinished
Effective start/end date7/15/066/30/20

Funding

  • National Institute on Aging

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