α1-Adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat

Michael T. Piascik; John W. Kusiak; Kirk W. Barron

doi:10.1016/0014-2999(90)90443-A

α₁-Adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat

Michael T. Piascik, John W. Kusiak, Kirk W. Barron

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The peripheral hemodynamic effects of SZL-49, a prazosin analog capable of selectively inactivating the α_1a-adrenoceptor subtype, was evaluated in the conscious rat. One hour after SZL-49 administration, total peripheral vascular resistance and arterial blood pressure significantly decreased and cardiac output and heart rate increased. Twenty-four hours after SZL-49, blood pressure returned to control preinjection levels while peripheral resistance remained decreased and cardiac output and heart rate were elevated. The phenylephrine dose-response curves for mean arterial blood pressure and total peripheral vascular resistance were shifted to the right but the maximal responses were not decreased. These data show that the α_1a receptor plays a role in the tonic maintenance of arterial blood pressure. The α_1b receptor appears to participate in the response to exogenously administered agonists.

Original language	English
Pages (from-to)	273-278
Number of pages	6
Journal	European Journal of Pharmacology
Volume	186
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(90)90443-A
State	Published - Sep 21 1990

Bibliographical note

Funding Information:
This work was supported by funds from the National Institutes of Health HL-38120 (to MTP), HL 36552 (to KWB), a Grant-in-aid from the American Heart Association (901244 to MTP), the American Heart Association-Kentucky Affiliate (to MTP and KWB) and KY-THRI 5-42078 (to KWB). The authors would like to thank Ruth Oremius and Terry Pruitt for their expert technical assistance.

Keywords

(Arterial blood pressure regulation)
Blood pressure (arterial)
α-Adrenoceptor subtypes
α-Adrenoceptors

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(90)90443-A

Cite this

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title = "α1-Adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat",

abstract = "The peripheral hemodynamic effects of SZL-49, a prazosin analog capable of selectively inactivating the α1a-adrenoceptor subtype, was evaluated in the conscious rat. One hour after SZL-49 administration, total peripheral vascular resistance and arterial blood pressure significantly decreased and cardiac output and heart rate increased. Twenty-four hours after SZL-49, blood pressure returned to control preinjection levels while peripheral resistance remained decreased and cardiac output and heart rate were elevated. The phenylephrine dose-response curves for mean arterial blood pressure and total peripheral vascular resistance were shifted to the right but the maximal responses were not decreased. These data show that the α1a receptor plays a role in the tonic maintenance of arterial blood pressure. The α1b receptor appears to participate in the response to exogenously administered agonists.",

keywords = "(Arterial blood pressure regulation), Blood pressure (arterial), α-Adrenoceptor subtypes, α-Adrenoceptors",

author = "Piascik, {Michael T.} and Kusiak, {John W.} and Barron, {Kirk W.}",

note = "Funding Information: This work was supported by funds from the National Institutes of Health HL-38120 (to MTP), HL 36552 (to KWB), a Grant-in-aid from the American Heart Association (901244 to MTP), the American Heart Association-Kentucky Affiliate (to MTP and KWB) and KY-THRI 5-42078 (to KWB). The authors would like to thank Ruth Oremius and Terry Pruitt for their expert technical assistance.",

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doi = "10.1016/0014-2999(90)90443-A",

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AU - Kusiak, John W.

AU - Barron, Kirk W.

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PY - 1990/9/21

Y1 - 1990/9/21

N2 - The peripheral hemodynamic effects of SZL-49, a prazosin analog capable of selectively inactivating the α1a-adrenoceptor subtype, was evaluated in the conscious rat. One hour after SZL-49 administration, total peripheral vascular resistance and arterial blood pressure significantly decreased and cardiac output and heart rate increased. Twenty-four hours after SZL-49, blood pressure returned to control preinjection levels while peripheral resistance remained decreased and cardiac output and heart rate were elevated. The phenylephrine dose-response curves for mean arterial blood pressure and total peripheral vascular resistance were shifted to the right but the maximal responses were not decreased. These data show that the α1a receptor plays a role in the tonic maintenance of arterial blood pressure. The α1b receptor appears to participate in the response to exogenously administered agonists.

AB - The peripheral hemodynamic effects of SZL-49, a prazosin analog capable of selectively inactivating the α1a-adrenoceptor subtype, was evaluated in the conscious rat. One hour after SZL-49 administration, total peripheral vascular resistance and arterial blood pressure significantly decreased and cardiac output and heart rate increased. Twenty-four hours after SZL-49, blood pressure returned to control preinjection levels while peripheral resistance remained decreased and cardiac output and heart rate were elevated. The phenylephrine dose-response curves for mean arterial blood pressure and total peripheral vascular resistance were shifted to the right but the maximal responses were not decreased. These data show that the α1a receptor plays a role in the tonic maintenance of arterial blood pressure. The α1b receptor appears to participate in the response to exogenously administered agonists.

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