Abstract
Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.
| Translated title of the contribution | Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models |
|---|---|
| Original language | English |
| Pages (from-to) | 603-610 |
| Number of pages | 8 |
| Journal | Journal of Zhejiang University: Science B |
| Volume | 21 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2020 |
Bibliographical note
Publisher Copyright:© 2020, Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords
- Angiotensin II (AngII)
- Hypertension
- Mouse model
- R543.1
- Thoracic aortic dissection (TAD)
- β-Aminopropionitrile (BAPN)
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Veterinary
- General Pharmacology, Toxicology and Pharmaceutics