Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models

Translated title of the contribution: Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models

Hai qiong Zheng, Jia bing Rong, Fei ming Ye, Yin chuan Xu, Hong S. Lu, Jian an Wang

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.

Translated title of the contributionInduction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
Original languageEnglish
Pages (from-to)603-610
Number of pages8
JournalJournal of Zhejiang University: Science B
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2020

Bibliographical note

Publisher Copyright:
© 2020, Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

  • Angiotensin II (AngII)
  • Hypertension
  • Mouse model
  • R543.1
  • Thoracic aortic dissection (TAD)
  • β-Aminopropionitrile (BAPN)

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Veterinary

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