Abstract
Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.
| Translated title of the contribution | Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models |
|---|---|
| Original language | Chinese (Simplified) |
| Pages (from-to) | 603-610 |
| Number of pages | 8 |
| Journal | Journal of Zhejiang University: Science B |
| Volume | 21 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2020 |
Bibliographical note
Funding Information:Project supported by the National Natural Science Foundation of China (Nos. 81870292 and 81971860) and the National Key Research and Development Program of China (No. 2016YFC1301204) Acknowledgments
Publisher Copyright:
© 2020, Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords
- Angiotensin II (AngII)
- Hypertension
- Mouse model
- R543.1
- Thoracic aortic dissection (TAD)
- β-Aminopropionitrile (BAPN)
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology (all)
- Veterinary (all)
- Pharmacology, Toxicology and Pharmaceutics (all)