β-Aminopropionitrile-induced aortic aneurysm and dissection in mice

Hisashi Sawada, Zachary A. Beckner, Sohei Ito, Alan Daugherty, Hong S. Lu

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The mechanistic basis for the formation of aortic aneurysms and dissection needs to be elucidated to facilitate the development of effective medications. β-Aminopropionitrile administration in mice has been used frequently to study the pathologic features and mechanisms of aortic aneurysm and dissection. This mouse model mimics several facets of the pathology of human aortic aneurysms and dissection, although many variables exist in the experimental design and protocols that must be resolved to determine its application to the human disease. In the present brief review, we have introduced the development of this mouse model and provided insights into understanding its pathologic features.

Original languageEnglish
Pages (from-to)64-72
Number of pages9
JournalJVS-Vascular Science
Volume3
DOIs
StatePublished - Jan 2022

Bibliographical note

Publisher Copyright:
© 2021 Society for Vascular Surgery

Keywords

  • Aortic aneurysms
  • Aortic dissection
  • Mouse
  • β-Aminopropionitrile

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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