Δ9-Tetrahydrocannabinol at Retrieval Drives False Recollection of Neutral and Emotional Memories

Manoj K. Doss, Jessica Weafer, David A. Gallo, Harriet de Wit

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: It is well established that the main psychoactive constituent of cannabis, Δ9-tetrahydrocannabinol (THC), impairs episodic memory encoding and modulates emotional processing, but little is known about the impact of THC during the retrieval of emotional episodic memories. With the rise of cannabis to treat medical conditions, including those characterized by emotional and episodic memory disturbances, there is an urgent need to determine the effects of THC on memory accuracy and distortion. Here, we report the first study investigating the effects of THC during retrieval of neutral and emotional episodic memories. Methods: Using a double-blind, placebo-controlled, within-subjects design, healthy volunteers (N = 23) viewed negative, neutral, and positive pictures (emotional memory task) and lists of semantically related words (false memory task). Forty-eight hours later, participants ingested a capsule containing either THC (15 mg) or placebo and completed tasks to test their memories for the previously studied pictures and words. Results: THC during retrieval did not reduce the number of correct responses to studied items. Instead, it robustly increased false recollection on both the emotional memory and false memory tasks. This effect was found for both neutral and emotional items. Conclusions: These findings show that THC has adverse effects during memory retrieval, distorting both neutral and emotional memories. Coupled with THC's known effects during encoding, these new retrieval findings are important in light of the spreading acceptance of cannabis.

Original languageEnglish
Pages (from-to)743-750
Number of pages8
JournalBiological Psychiatry
Volume84
Issue number10
DOIs
StatePublished - Nov 15 2018

Bibliographical note

Funding Information:
HdW has received a GRAND research award from Pfizer, donation of a study drug from Indivior, support for a research study from Insys Therapeutics, and consulting fees from Bristol-Myers-Squibb, Jazz Pharmaceuticals, Marinus, and Organon. None of these were related to the research presented here. The other authors report no biomedical financial interests or potential conflicts of interest.

Funding Information:
This project was supported by Grant No. DA02812 (to HdW). We thank lab personnel who recruited and screened participants and Royce Lee, M.D., for medical oversight. HdW has received a GRAND research award from Pfizer, donation of a study drug from Indivior, support for a research study from Insys Therapeutics, and consulting fees from Bristol-Myers-Squibb, Jazz Pharmaceuticals, Marinus, and Organon. None of these were related to the research presented here. The other authors report no biomedical financial interests or potential conflicts of interest. ClinicalTrials.gov: Effects of THC on Emotional Memory Retrieval; https://clinicaltrials.gov/ct2/show/NCT03471585; NCT03471585.

Publisher Copyright:
© 2018 Society of Biological Psychiatry

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Cannabis
  • Emotional memory
  • Episodic memory
  • False memory
  • False recollection
  • THC

ASJC Scopus subject areas

  • Biological Psychiatry

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