TY - JOUR
T1 - (11R)-13-(1-Naphthylmethylamino)-4,5-epoxy-11,13-dihydrocostunolide
AU - Nasim, Shama
AU - Parkin, Sean
AU - Crooks, Peter A.
PY - 2007/10/5
Y1 - 2007/10/5
N2 - Crystals of the title compound, C26H31NO3, were obtained by the reaction of 1-naphthyl-methyl-amine with parthenolide. X-ray crystal structure determination reveals a stacked conformation between the cyclo-decane ring of the parthenol-ide moiety and the pendant naphthalene ring. The configuration of the new chiral center at C11 (the point of attachment of the naphthyl-methyl-amino side group) in the title compound is R, establishing the stereospecificity of the amination reaction.
AB - Crystals of the title compound, C26H31NO3, were obtained by the reaction of 1-naphthyl-methyl-amine with parthenolide. X-ray crystal structure determination reveals a stacked conformation between the cyclo-decane ring of the parthenol-ide moiety and the pendant naphthalene ring. The configuration of the new chiral center at C11 (the point of attachment of the naphthyl-methyl-amino side group) in the title compound is R, establishing the stereospecificity of the amination reaction.
UR - http://www.scopus.com/inward/record.url?scp=35948951186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35948951186&partnerID=8YFLogxK
U2 - 10.1107/S1600536807046983
DO - 10.1107/S1600536807046983
M3 - Article
AN - SCOPUS:35948951186
SN - 1600-5368
VL - 63
SP - o4274
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
IS - 11
ER -