(11R)-13-(1-Naphthylmethylamino)-4,5-epoxy-11,13-dihydrocostunolide

Shama Nasim, Sean Parkin, Peter A. Crooks

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Crystals of the title compound, C26H31NO3, were obtained by the reaction of 1-naphthyl-methyl-amine with parthenolide. X-ray crystal structure determination reveals a stacked conformation between the cyclo-decane ring of the parthenol-ide moiety and the pendant naphthalene ring. The configuration of the new chiral center at C11 (the point of attachment of the naphthyl-methyl-amino side group) in the title compound is R, establishing the stereospecificity of the amination reaction.

Original languageEnglish
Pages (from-to)o4274
JournalActa Crystallographica Section E: Structure Reports Online
Volume63
Issue number11
DOIs
StatePublished - Oct 5 2007

ASJC Scopus subject areas

  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics

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