TY - JOUR
T1 - (11R)-13-[2-(4-Hydroxyphenyl)ethyl-amino]-4,5-epoxy-11,13-dihydro- costunolide monohydrate
AU - Nasim, Shama
AU - Parkin, Sean
AU - Crooks, Peter A.
PY - 2008
Y1 - 2008
N2 - The title compound (systematic name: 12-{[2-(4-hydroxyphenyl)ethyl] aminomethyl}-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7- en-13-one monohydrate), C23H31NO4·H2O, was obtained by the reaction of tyramine with parthenolide. The configuration of the new chiral center in the title compound is R, establishing the stereospecificity of the amination reaction. The water molecule is disordered over three positions; the site occupancy factors are 0.45, 0.40 and 0.15.
AB - The title compound (systematic name: 12-{[2-(4-hydroxyphenyl)ethyl] aminomethyl}-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7- en-13-one monohydrate), C23H31NO4·H2O, was obtained by the reaction of tyramine with parthenolide. The configuration of the new chiral center in the title compound is R, establishing the stereospecificity of the amination reaction. The water molecule is disordered over three positions; the site occupancy factors are 0.45, 0.40 and 0.15.
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U2 - 10.1107/S1600536808003863
DO - 10.1107/S1600536808003863
M3 - Article
C2 - 21201974
AN - SCOPUS:40249094642
SN - 1600-5368
VL - 64
SP - o644
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
IS - 3
ER -