(11R)-13-[2-(4-Hydroxyphenyl)ethyl-amino]-4,5-epoxy-11,13-dihydro- costunolide monohydrate

Shama Nasim, Sean Parkin, Peter A. Crooks

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The title compound (systematic name: 12-{[2-(4-hydroxyphenyl)ethyl] aminomethyl}-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7- en-13-one monohydrate), C23H31NO4·H2O, was obtained by the reaction of tyramine with parthenolide. The configuration of the new chiral center in the title compound is R, establishing the stereospecificity of the amination reaction. The water molecule is disordered over three positions; the site occupancy factors are 0.45, 0.40 and 0.15.

Original languageEnglish
Pages (from-to)o644
JournalActa Crystallographica Section E: Structure Reports Online
Volume64
Issue number3
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics

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