(11R)-13-Dimethylammonio-11,13-dihydro-4,5-epoxycostunolide semifumarate

Sundar Neelakantan, Sean Parkin, Peter A. Crooks

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Crystals of the title salt, C17H28NO 3+·C4H3O4-, were obtained by reacting parthenolide with dimethylamine followed by conversion of the amine adduct into a water-soluble fumarate salt. Subsequent crystallization of the fumarate salt from water afforded colorless orthorhombic crystals. The amine addition is highly stereospecific yielding exclusively a single diastereomer with R-configuration at the newly formed C-11 chiral carbon. In the crystal, intermolecular O?H⋯O and N?H⋯O hydrogen bonds help to establish the packing.

Original languageEnglish
Pages (from-to)o1569
JournalActa Crystallographica Section E: Structure Reports Online
Issue number7
StatePublished - 2009

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics


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