1/f Fluctuations in arterial pressure and regulation of renal blood flow in dogs

D. J. Marsh, J. L. Osborn, A. W. Cowley

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

To determine whether renal blood flow is regulated against spontaneous fluctuations in arterial pressure and to estimate the frequency band of the regulation, we measured arterial pressure and renal blood flow continuously over several days in conscious dogs. Mean arterial blood pressure showed broad band fluctuations and behaved as a 1/f process, indicating that blood pressure record is a fractal curve and therefore scale invariant. The fluctuations in arterial pressure caused attenuated fluctuations in renal blood flow; the gain was about -6.5 ± 0.5 dB through all sampled frequencies ≥4 cycle/day. The kidney did not attenuate the blood pressure signal at the lowest frequencies. The results show that renal blood flow is better regulated against fluctuations in pressure at frequencies ≥4 cycle/day than it is at lower frequencies. Although there are no direct tests of the underlying regulatory mechanisms, we argue that the responses are generated locally and can be identified with renal autoregulation.

Original languageEnglish
Pages (from-to)F1394-F1400
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume258
Issue number5 27-5
DOIs
StatePublished - 1990

Keywords

  • autoregulation
  • fractals
  • power spectral density analysis

ASJC Scopus subject areas

  • Physiology

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