Problematic ipso substitution was observed in the Suzuki-Miyaura coupling of pentafluorophenylboronic acid to make 2-pentafluorophenylpyridine. Strong bases favored coupling, but under these conditions fluorine in the product tended to undergo nucleophilic substitution. Inclusion of Ag2O accelerated coupling over ipso substitution.
|Number of pages||4|
|State||Published - Feb 10 2003|
Bibliographical noteFunding Information:
The authors thank the NSF (0111578) for financial support.
- Aryl cross coupling
- Pd catalyst
- Suzuki coupling
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry