TY - JOUR
T1 - 20-Hydroxyecdysone (20E) primary response gene E93 modulates 20E signaling to promote bombyx larval-pupal metamorphosis
AU - Liu, Xi
AU - Dai, Fangyin
AU - Guo, Enen
AU - Li, Kang
AU - Ma, Li
AU - Tian, Ling
AU - Cao, Yang
AU - Zhang, Guozheng
AU - Palli, Subba R.
AU - Li, Sheng
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2015/11/6
Y1 - 2015/11/6
N2 - Background: 20-Hydroxyecdysone (20E) and juvenile hormone (JH) coordinately control insect molting and metamorphosis. Results: Induced by 20E and suppressed by JH, E93 acts through GAGA-containing motifs and up-regulates a subset of 20E response genes. Conclusion: E93 transcriptionally modulates 20E signaling to promote Bombyx metamorphosis. Significance: Our study helps in understanding the complicated molecular mechanisms of insect metamorphosis.
AB - Background: 20-Hydroxyecdysone (20E) and juvenile hormone (JH) coordinately control insect molting and metamorphosis. Results: Induced by 20E and suppressed by JH, E93 acts through GAGA-containing motifs and up-regulates a subset of 20E response genes. Conclusion: E93 transcriptionally modulates 20E signaling to promote Bombyx metamorphosis. Significance: Our study helps in understanding the complicated molecular mechanisms of insect metamorphosis.
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U2 - 10.1074/jbc.M115.687293
DO - 10.1074/jbc.M115.687293
M3 - Article
C2 - 26378227
AN - SCOPUS:84946615286
SN - 0021-9258
VL - 290
SP - 27370
EP - 27383
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 45
ER -