20-Hydroxyecdysone (20E) primary response gene E93 modulates 20E signaling to promote bombyx larval-pupal metamorphosis

Xi Liu, Fangyin Dai, Enen Guo, Kang Li, Li Ma, Ling Tian, Yang Cao, Guozheng Zhang, Subba R. Palli, Sheng Li

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Background: 20-Hydroxyecdysone (20E) and juvenile hormone (JH) coordinately control insect molting and metamorphosis. Results: Induced by 20E and suppressed by JH, E93 acts through GAGA-containing motifs and up-regulates a subset of 20E response genes. Conclusion: E93 transcriptionally modulates 20E signaling to promote Bombyx metamorphosis. Significance: Our study helps in understanding the complicated molecular mechanisms of insect metamorphosis.

Original languageEnglish
Pages (from-to)27370-27383
Number of pages14
JournalJournal of Biological Chemistry
Volume290
Issue number45
DOIs
StatePublished - Nov 6 2015

Bibliographical note

Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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