3.26 - Mammalian Odorant Receptor Gene Regulation

Timothy S. McClintock

doi:10.1016/B978-0-12-809324-5.23796-6

3.26 - Mammalian Odorant Receptor Gene Regulation

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Mammals cope with the vast diversity of odor molecules by employing hundreds of odorant receptors (ORs). Each mature olfactory sensory neuron expresses only one allele of one OR gene, an adaptation that maximizes odor discrimination ability. This specificity is achieved via a developmental program of epigenetic repression and segregation of OR gene loci into compartments within the nucleus, rescue of a few OR genes from repression in each immature neuron, and an unprecedented mechanism involving interchromosomal interactions between OR gene enhancers to trigger strong expression of a single OR allele and the final maturation of the sensory neuron.

Original language	English
Title of host publication	The Senses
Subtitle of host publication	A Comprehensive Reference: Volume 1-7, Second Edition
Pages	536-544
Number of pages	9
Volume	3
ISBN (Electronic)	9780128054093
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.23796-6
State	Published - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.

Keywords

Chromatin modification
Epigenetics
Gene duplication
Gene enhancer
Gene promoter
Gene silencing
Heterochromatin
Neural development
Nuclear compartment
Odor discrimination
Odorant receptor
Olfactory epithelium
Olfactory sensory neuron
Trans-chromosomal interactions
Transcription factor

ASJC Scopus subject areas

Medicine (all)
Neuroscience (all)

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10.1016/B978-0-12-809324-5.23796-6

Cite this

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abstract = "Mammals cope with the vast diversity of odor molecules by employing hundreds of odorant receptors (ORs). Each mature olfactory sensory neuron expresses only one allele of one OR gene, an adaptation that maximizes odor discrimination ability. This specificity is achieved via a developmental program of epigenetic repression and segregation of OR gene loci into compartments within the nucleus, rescue of a few OR genes from repression in each immature neuron, and an unprecedented mechanism involving interchromosomal interactions between OR gene enhancers to trigger strong expression of a single OR allele and the final maturation of the sensory neuron.",

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KW - Gene silencing

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KW - Olfactory epithelium

KW - Olfactory sensory neuron

KW - Trans-chromosomal interactions

KW - Transcription factor

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3.26 - Mammalian Odorant Receptor Gene Regulation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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