5-HT(1B) antagonists modulate clearance of extracellular serotonin in rat hippocampus

Lynette C. Daws, Greg A. Gerhardt, Alan Frazer

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

In vivo chronoamperometry was used to determine the effects of locally applied antagonists of the serotonin-1B (5-HT(1B)) receptor (cyanopindolol, 5-HT-moduline and methiothepin) on the clearance of 5-HT in the CA3 region of the dorsal hippocampus and the corpus callosum (a brain region devoid of serotonin transporters and 5-HT(1B) receptors) of the rat. When 5-HT was pressure ejected into these regions, reproducible signals were detected. In the CA3 region, local application of 5-HT(1B) antagonists decreased the rate of clearance of the serotonin signal comparably to the selective 5-HT uptake inhibitor (SSRI), fluvoxamine. By contrast, in the corpus callosum, none of the drugs altered the 5-HT signal. One interpretation of these data is that 5-HT(1B) receptors can modulate the activity of the 5-HT transporter.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNeuroscience Letters
Volume266
Issue number3
DOIs
StatePublished - May 14 1999

Bibliographical note

Funding Information:
This work was supported by United States Public Health Service Grants MH57001, AG06434 and NS09199 and funds from the Veterans Administration. The authors would like to thank Susan Teicher and Georgianna Gould for excellent technical assistance and Dr. Michael A. Rea, Brooks Airforce Base, San Antonio, TX, for the generous gift of 5-HT moduline.

Keywords

  • 5-HT(1B) receptor
  • 5-HT-moduline
  • Cyanopindolol
  • Hippocampus
  • In vivo chronoamperometry
  • Serotonin transporter

ASJC Scopus subject areas

  • General Neuroscience

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