A δ-lactone synthesis involving an intramolecular 1,4-addition of α-iodoacetates to enones

Ayhan S. Demir; Raymond S. Gross; Norma K. Dunlap; A. Bashir-Hashemi; David S. Watt

doi:10.1016/S0040-4039(00)85267-3

A δ-lactone synthesis involving an intramolecular 1,4-addition of α-iodoacetates to enones

Ayhan S. Demir
, Raymond S. Gross
, Norma K. Dunlap
, A. Bashir-Hashemi
, David S. Watt

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A cyclization of δ-(iodoacetoxy)-α,β-unsaturated ketones using iodotrimethylsilane involved a selective 1,4-addition of the acetate subunit to the enone and furnished δ-lactones in good yield.

Original language	English
Pages (from-to)	5567-5570
Number of pages	4
Journal	Tetrahedron Letters
Volume	27
Issue number	46
DOIs	https://doi.org/10.1016/S0040-4039(00)85267-3
State	Published - 1986

Funding

Acknowledgement. We thank the National Institutes of Health (GM 36256) for their generous support and Drs. K. Drauz and M. Bernd of Degussa AG, Hanau for a generous gift of chemicals.

Funders	Funder number
National Institutes of Health (NIH)	GM 36256

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)85267-3

Cite this

@article{ad2fdefda30d43b2bb1b01d2dfd37e0e,

title = "A δ-lactone synthesis involving an intramolecular 1,4-addition of α-iodoacetates to enones",

abstract = "A cyclization of δ-(iodoacetoxy)-α,β-unsaturated ketones using iodotrimethylsilane involved a selective 1,4-addition of the acetate subunit to the enone and furnished δ-lactones in good yield.",

author = "Demir, \{Ayhan S.\} and Gross, \{Raymond S.\} and Dunlap, \{Norma K.\} and A. Bashir-Hashemi and Watt, \{David S.\}",

year = "1986",

doi = "10.1016/S0040-4039(00)85267-3",

language = "English",

volume = "27",

pages = "5567--5570",

number = "46",

}

TY - JOUR

T1 - A δ-lactone synthesis involving an intramolecular 1,4-addition of α-iodoacetates to enones

AU - Demir, Ayhan S.

AU - Gross, Raymond S.

AU - Dunlap, Norma K.

AU - Bashir-Hashemi, A.

AU - Watt, David S.

PY - 1986

Y1 - 1986

N2 - A cyclization of δ-(iodoacetoxy)-α,β-unsaturated ketones using iodotrimethylsilane involved a selective 1,4-addition of the acetate subunit to the enone and furnished δ-lactones in good yield.

AB - A cyclization of δ-(iodoacetoxy)-α,β-unsaturated ketones using iodotrimethylsilane involved a selective 1,4-addition of the acetate subunit to the enone and furnished δ-lactones in good yield.

UR - https://www.scopus.com/pages/publications/0000769669

UR - https://www.scopus.com/pages/publications/0000769669#tab=citedBy

U2 - 10.1016/S0040-4039(00)85267-3

DO - 10.1016/S0040-4039(00)85267-3

M3 - Article

AN - SCOPUS:0000769669

SN - 0040-4039

VL - 27

SP - 5567

EP - 5570

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

A δ-lactone synthesis involving an intramolecular 1,4-addition of α-iodoacetates to enones

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this